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Moving with the kines: Chemokine receptor expression regulates the migration and differentiation of IgG4‐expressing B cells
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-07-06 , DOI: 10.1002/eji.202048802 Lou Salomé Herman 1 , Louisa Katherine James 1
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-07-06 , DOI: 10.1002/eji.202048802 Lou Salomé Herman 1 , Louisa Katherine James 1
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IgG4 is the least abundant of the human IgG subclasses and for decades was only a curiosity among allergists, who spent several years debating its role in immune tolerance. Among the unusual features of IgG4, an inability to form immune complexes or engage with Fc receptors and complement cemented its place as a protolerogenic subclass, capable of inhibiting the potent effects of IgE. However, when reports emerged that a diverse set of fibrotic diseases were linked by the expansion of IgG4‐producing plasma cells, questions were raised about the role of IgG4 in immune‐mediated pathology. Understanding the biology of IgG4 has therefore taken on a new sense of importance. In this issue of the European Journal of Immunology , Unger et al . [Eur. J. Immunol. 2020. 50: 1113–1125] demonstrate that human IgG4+ B cells have reduced expression of several key chemokine receptors and this limits their ability to access secondary lymphoid tissue and differentiate to long‐lived plasma cells leading to selective reduction of IgG4 following CD20+ B cell depletion with Rituximab. We discuss these findings in the context of the unusual properties of IgG4 and speculate on the role of IgG4‐producing cells in the resolution of inflammation.
中文翻译：
顺应潮流：趋化因子受体表达调节表达IgG4的B细胞的迁移和分化
IgG4是人类IgG亚类中含量最少的，几十年来，这只是过敏学家的好奇心，他们花了几年时间讨论了其在免疫耐受中的作用。IgG4的异常特征之一是无法形成免疫复合物或与Fc受体结合并无法补充其作为促致癌性亚类的地位，能够抑制IgE的强效作用。但是，当有报道称，各种类型的纤维化疾病与产生IgG4的浆细胞的膨胀有关时，关于IgG4在免疫介导的病理学中的作用提出了疑问。因此，对IgG4生物学的理解有了新的重要性。在本期《欧洲免疫学杂志》中，Unger等。[欧元。J.免疫。2020. 50：1113-1125]证明人IgG4 + B细胞减少了几种关键趋化因子受体的表达，这限制了它们进入次级淋巴组织的能力，并分化为长寿浆细胞，导致CD20 + B后选择性降低IgG4利妥昔单抗清除细胞。我们将在IgG4异常特性的背景下讨论这些发现，并推测产生IgG4的细胞在解决炎症中的作用。
更新日期：2020-08-04
中文翻译：
顺应潮流：趋化因子受体表达调节表达IgG4的B细胞的迁移和分化
IgG4是人类IgG亚类中含量最少的，几十年来，这只是过敏学家的好奇心，他们花了几年时间讨论了其在免疫耐受中的作用。IgG4的异常特征之一是无法形成免疫复合物或与Fc受体结合并无法补充其作为促致癌性亚类的地位，能够抑制IgE的强效作用。但是，当有报道称，各种类型的纤维化疾病与产生IgG4的浆细胞的膨胀有关时，关于IgG4在免疫介导的病理学中的作用提出了疑问。因此，对IgG4生物学的理解有了新的重要性。在本期《欧洲免疫学杂志》中，Unger等。[欧元。J.免疫。2020. 50：1113-1125]证明人IgG4 + B细胞减少了几种关键趋化因子受体的表达，这限制了它们进入次级淋巴组织的能力，并分化为长寿浆细胞，导致CD20 + B后选择性降低IgG4利妥昔单抗清除细胞。我们将在IgG4异常特性的背景下讨论这些发现，并推测产生IgG4的细胞在解决炎症中的作用。
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