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N-glycosylation in Archaea-New roles for an ancient posttranslational modification.
Molecular Microbiology ( IF 2.6 ) Pub Date : 2020-07-07 , DOI: 10.1111/mmi.14569
Jerry Eichler 1
Affiliation  

Genome analysis points to N‐glycosylation as being an almost universal posttranslational modification in Archaea. Although such predictions have been confirmed in only a limited number of species, such studies are making it increasingly clear that the N‐linked glycans which decorate archaeal glycoproteins present diversity in terms of both glycan composition and architecture far beyond what is seen in the other two domains of life. In addition to continuing to decipher pathways of N‐glycosylation, recent efforts have revealed how Archaea exploit this variability in novel roles. As well as encouraging glycoprotein synthesis, folding and assembly into properly functioning higher ordered complexes, N‐glycosylation also provides Archaea with a strategy to cope with changing environments. Archaea can, moreover, exploit the apparent species‐specific nature of N‐glycosylation for selectivity in mating, and hence, to maintain species boundaries, and in other events where cell‐selective interactions are required. At the same time, addressing components of N‐glycosylation pathways across archaeal phylogeny offers support for the concept of an archaeal origin for eukaryotes. In this MicroReview, these and other recent discoveries related to N‐glycosylation in Archaea are considered.

中文翻译:

古细菌中的 N-糖基化-古代翻译后修饰的新作用。

基因组分析指出,N-糖基化是古细菌中几乎普遍的翻译后修饰。尽管此类预测仅在有限数量的物种中得到证实,但此类研究越来越清楚地表明,装饰古菌糖蛋白的 N-连接聚糖在聚糖组成和结构方面表现出的多样性远远超过其他两种生活领域。除了继续破译 N-糖基化途径之外,最近的努力还揭示了古细菌如何在新的角色中利用这种可变性。除了促进糖蛋白合成、折叠和组装成功能正常的高级复合物外,N-糖基化还为古细菌提供了应对不断变化的环境的策略。此外,古细菌可以 利用 N-糖基化的明显物种特异性特性,在交配中具有选择性,从而保持物种边界,以及在需要细胞选择性相互作用的其他事件中。同时,解决古菌系统发育中 N-糖基化途径的组成部分为真核生物古菌起源的概念提供了支持。在此 MicroReview 中,考虑了与古细菌中 N-糖基化相关的这些和其他最新发现。
更新日期:2020-07-07
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