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Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-07-07 , DOI: 10.1002/anie.202008426
Johannes H. Harenberg 1 , Niels Weidmann 1 , Paul Knochel 1
Affiliation  

Metalation of functionalized (hetero)arenes with KDA (potassium diisopropylamide)/TMEDA was performed using a commercial continuous flow set‐up leading to the corresponding potassium organometallics. In their Communication (DOI: 10.1002/anie.202003392), P. Knochel et al. show that trapping with various electrophiles gives polyfunctionalized (hetero)aromatics in good yields. The flow procedure was extended to the lateral metalation of methyl‐substituted (hetero)arenes resulting in benzylic potassium organometallics, which were trapped with various electrophiles.
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中文翻译:

二异丙基氨基钾连续流动制备功能化的芳基,杂芳基和苄基有机金属钾

使用商业连续流装置,使用KDA(二异丙基氨基钾)/ TMEDA进行官能化(杂)芳烃的金属化反应,得到相应的有机金属钾盐。在他们的交流中(DOI:10.1002 / anie.202003392),P。Knochel等人。结果表明,用各种亲电试剂捕集可得到高收率的多官能化(杂)芳烃。该流程扩展到了甲基取代(杂)芳烃的侧向金属化反应,生成了苄基钾有机金属,并被各种亲电子试剂捕获。
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更新日期:2020-07-07
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