Objective

Postoperative cognitive dysfunction (POCD) may be related to brain injury. S100B protein and neuron-specific enolase (NSE) have been investigated as potential biochemical markers of neural cell injury in animals and humans. This study aimed to investigate the association between POCD, brain injury and serum concentrations of S100B and NSE after periodontal surgery in aged dogs.

Study design

Prospective observational animal study.

Animals

A total of 24 male and female dogs undergoing periodontal surgery.

Methods

Dogs were separated into two groups based on age: control group, 10 dogs ≤ 8 years and aged group, 14 dogs > 8 years. Cognitive function was measured preoperatively and on the seventh postoperative day using the Canine Cognitive Dysfunction Rating scale and the Age-Related Cognitive and Affective Disorders scale. S100B protein and NSE serum concentrations were measured before and immediately after the surgery.

Results

POCD was not observed after surgery in the present study. Serum concentrations of S100B and NSE were increased postoperatively in the control group but not in the aged group (p = 0.04 and 0.03, respectively). Preoperative S100B serum concentrations were significantly higher in the aged group (p = 0.01).

Conclusions

There was no association between POCD and high concentrations of S100B and NSE in dogs. However, increased postoperative serum concentrations of S100B and NSE were found in the control group after surgery, an effect that may indicate neural damage.

Clinical relevance

The results suggest that anesthesia and oral surgery are associated with higher postoperative serum concentrations of S100B and NSE in dogs ≤ 8 years old, which may indicate neural damage. Serum concentrations of S100B were elevated in aged dogs before anesthesia, a finding that might be related to chronic preoperative brain damage.

中文翻译：

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S100B蛋白和神经元特异性烯醇化酶预测老年犬术后认知功能障碍：病例对照研究。

目的

术后认知功能障碍（POCD）可能与脑损伤有关。已经研究了S100B蛋白和神经元特异性烯醇化酶（NSE）作为动物和人类神经细胞损伤的潜在生化标记。本研究旨在探讨老年犬牙周手术后POCD，脑损伤与S100B和NSE血清浓度之间的关系。

学习规划

前瞻性观察性动物研究。

动物

共有24只进行牙周手术的雌雄狗。

方法

根据年龄将狗分为两组：对照组，≤8岁的10只狗和年龄大于8岁的14只狗。术前和术后第七天使用犬认知障碍评估量表和与年龄有关的认知与情感障碍量表对认知功能进行测量。在手术之前和之后立即测量S100B蛋白和NSE血清浓度。

结果

在本研究中，术后未观察到POCD。对照组S100B和NSE的血清浓度在术后增加，但在老年组则没有增加（ 分别为p = 0.04和0.03）。老年组患者术前S100B血清浓度显着升高（p  = 0.01）。

结论

在狗中，POCD与高浓度的S100B和NSE之间没有关联。但是，术后对照组中发现S100B和NSE的血清浓度升高，这可能表明神经损伤。

临床相关性

结果表明，麻醉和口腔手术与≤8岁狗的术后血清S100B和NSE较高的血清浓度有关，这可能表明神经损伤。麻醉前，成年犬的血清S100B浓度升高，这一发现可能与慢性术前脑损伤有关。