In this issue of Structure, Urbanek et al. (2020a) combine site-specific isotope labeling and NMR spectroscopy to investigate opposing effects of flanking regions onto the conformation of the poly-Q region in Huntingtin. Poly-Q interactions with preceding residues promote an α-helical conformation while a following proline-rich region favors extended conformations.

中文翻译：

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当少即是多时：结合特定地点的同位素标记和NMR揭示亨廷顿重复序列的结构细节。

在本期《结构》中，Urbanek等人。（2020a）结合位点特异性同位素标记和NMR光谱研究在Huntingtin中侧翼区对poly-Q区构象的相反影响。与前面残基的Poly-Q相互作用促进α-螺旋构象，而后面富含脯氨酸的区域则有利于延长构象。