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Oxidative cyclization of linoleic acid in the presence of hydrogen peroxide and phosphotungstic acid
Molecular Catalysis ( IF 3.9 ) Pub Date : 2020-07-07 , DOI: 10.1016/j.mcat.2020.111084
Nahla Araji , Gregory Chatel , Audrey Moores , François Jérôme , Karine De Oliveira Vigier

The synthesis of THF and tetrahydro-2H-pyrane is of interest due to the applications of such molecules as antitumour, pesticidal, antiprotozoal and antimicrobial agents for instance. Here, an original approach was performed to prepare these derivatives starting from linoleic acid in the presence of hydrogen peroxide and phosphotungstic acid in the absence of a phase transfer agent. A maximum cyclic compounds yield of 99 % was obtained under mild conditions of temperature. A heterogeneous catalyst was synthesized by exchanging proton by Cs to obtain Cs2,3H0,7PW12O40 that was recycled up to 3 cycles. It is one of the best yield to these products observed in the literature from fatty acids.



中文翻译:

在过氧化氢和磷钨酸存在下亚油酸的氧化环化

THF和四氢-2H-吡喃的合成由于诸如抗肿瘤剂,杀虫剂,抗原生动物剂和抗微生物剂之类的分子的应用而受到关注。在此,进行了原始方法以在过氧化氢和磷钨酸存在下,在不存在相转移剂的情况下从亚油酸开始制备这些衍生物。在温和的温度条件下获得的最大环状化合物收率为99%。通过将质子与Cs交换来合成非均相催化剂,以获得Cs 2,3 H 0,7 PW 12 O 40,其循环使用最多3个循环。这是从脂肪酸文献中观察到的这些产物的最佳收率之一。

更新日期:2020-07-07
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