With the downsizing of metal sizes (nanoparticles, nanoclusters, and single atoms), the catalytic behaviors of supported metal species change significantly for various chemical transformations. The metal-support interaction (MSI) is believed to play a critical role in tuning the catalytic behavior of supported metal species. However, the diversity of MSI because of the size effects of metal species and distinct surface properties of various substrates makes the development of global knowledge on MSI very difficult. Therefore, it is highly desired to distinguish the influence of those two factors in determining the MSI so that better practical catalysts can be designed. In this review, the influence of metal size on MSI in various supports (oxide, carbon, phosphide, nitride, sulfide, and metal) will be particularly discussed. Moreover, the catalytic applications of MSI for various chemical transformations, including thermocatalytic reactions, electrocatalytic reactions, and so on, will be incorporated. In addition, the dynamic evolution of MSI under reaction condition will be discussed. Last but not least, we will give perspectives on utilizing MSI in the community of catalysis.

随着金属尺寸（纳米粒子，纳米团簇和单原子）尺寸的减小，负载的金属物种的催化行为对于各种化学转化会发生显着变化。据信金属-载体相互作用（MSI）在调节负载的金属物质的催化行为中起关键作用。但是，由于金属种类的尺寸效应和各种基材独特的表面特性，MSI的多样性使开发有关MSI的全球知识变得非常困难。因此，非常需要在确定MSI时区分这两个因素的影响，以便可以设计更好的实用催化剂。在这篇综述中，将特别讨论金属尺寸对各种载体（氧化物，碳，磷化物，氮化物，硫化物和金属）中MSI的影响。此外，将结合MSI在各种化学转化中的催化应用，包括热催化反应，电催化反应等。此外，还将讨论反应条件下微星的动态演化。最后但并非最不重要的一点，我们将给出在催化领域利用MSI的观点。