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Genetic diversity, admixture and the effect of inbreeding on milk performance in two autochthonous goat breeds
Livestock Science ( IF 1.8 ) Pub Date : 2020-07-07 , DOI: 10.1016/j.livsci.2020.104163
H. Vostra-Vydrova , B. Hofmanova , N. Moravcikova , J. Rychtarova , R. Kasarda , K. Machova , M. Brzakova , L. Vostry

For the development of an appropriate program for the conservation of animal genetic resources, careful evaluation of the current genetic diversity in endangered breeds was performed. Pedigree data from a total of 38,288 animals registered in studbooks between 1970 and 2017 from two autochthonous Czech goat breeds, White and Brown Shorthair goats, were analysed to identify factors that may have affected the genetic variability of the breeds. Because the populations of both breeds are closed, there is concern about the loss of genetic variation. The average numbers of equivalent complete generations were 10 and 11 for White Shorthair goat and Bowen Shorthair goat, respectively. The effective numbers of founders contributing to the current genetic pool were 323 and 45, and the effective numbers of ancestors were 90 and 24, respectively. The average inbreeding and relatedness coefficients for the reference populations of the two breeds were 2% and 5.3%, respectively, for White Shorthair goats and 3.7 and 11.5% for Brown Shorthair goats. The corresponding estimates of the effective population size based on an increase in inbreeding or coancestry were 244 and 311, respectively, for White Shorthair goats and 82 and 87 for Brown Shorthair goats. Three kinds of inbreeding coefficients, the classical inbreeding coefficient, the new inbreeding coefficient and the ancestral inbreeding coefficient, were used to quantify the effects of inbreeding and purging on milk production in both analysed breeds. All tested inbreeding coefficients (FX, Fnew) showed a significantly negative influence on milk performance in the White Shorthair goat breed. The purging effect was confirmed based on the difference between FX and Fnew in White Shorthair goats and on the suitability of the statistical model in Brown Shorthair goats. These statistics suggest that genetic variability has decreased and inbreeding depression has occurred and that without changes in the breeding strategy, genetic variability might continue to decline.



中文翻译:

两种土生山羊品种的遗传多样性,混合物及近交对产奶性能的影响

为了制定适当的动物遗传资源保护计划,对濒危品种的当前遗传多样性进行了认真评估。从1970年到2017年之间,在育种簿中注册的38288只动物的家谱数据进行了分析,以分析可能影响该品种遗传变异性的因素,包括捷克的两个土生土长的捷克山羊品种White和Brown Shorthair山羊。由于两个品种的种群都是封闭的,因此担心遗传变异的丧失。White Shorthair山羊和Bowen Shorthair山羊的等效完整世代的平均数分别为10和11。对当前遗传库做出贡献的创建者的有效数量分别为323和45,祖先的有效数量分别为90和24。这两个品种的参考种群的平均近亲繁殖系数和相关系数分别为:白色短毛山羊2%和5.3%,棕色短毛山羊3.7和11.5%。基于近亲繁殖或亲缘关系增加的有效种群规模的相应估计,白短毛山羊分别为244和311,棕短毛山羊分别为82和87。三种近交系数,即经典近交系数,新近交系数和祖先近交系数,用于量化两个被分析品种中近交和清除对奶产量的影响。所有测试的近交系数(F 棕色短毛山羊分别为7和11.5%。基于近亲繁殖或亲缘关系增加的有效种群规模的相应估计,白短毛山羊分别为244和311,棕短毛山羊分别为82和87。三种近交系数,即经典近交系数,新近交系数和祖先近交系数,用于量化两个被分析品种中近交和清除对奶产量的影响。所有测试的近交系数(F 棕短毛山羊分别为7和11.5%。基于近亲繁殖或亲缘关系增加的有效种群规模的相应估计,白短毛山羊分别为244和311,棕短毛山羊分别为82和87。三种近交系数,即经典近交系数,新近交系数和祖先近交系数,用于量化两个被分析品种中近交和清除对奶产量的影响。所有测试的近交系数(F 传统的近交系数,新近交系数和祖先近交系数用于量化两个被分析品种的近交和清除对奶产量的影响。所有测试的近交系数(F 传统的近交系数,新近交系数和祖先近交系数被用于量化两个被分析品种中近交和清除对奶产量的影响。所有测试的近交系数(FX,F new)对White Shorthair山羊品种的牛奶生产表现出显着的负面影响。根据白色短毛山羊的F X和F new之间的差异以及棕色短毛山羊统计模型的适用性,确定了净化效果。这些统计数据表明,遗传变异性已经降低,近亲衰退发生了,并且如果不改变育种策略,遗传变异性可能会继续下降。

更新日期:2020-07-07
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