Abstract In this study, the effects of Pseudomonas quinolone signal (PQS) based quorum quenching (QQ) on biofouling control and the mitigated biofouling on the rejection of pharmaceutically active compounds (PhACs) i.e., carbamazepine (CBZ) and sulfamethoxazole (SMZ) in forward osmosis (FO) were systematically investigated. The results showed that methyl anthranilate (MA), the inhibitor of the PQS pathway, efficiently alleviated biofouling. Compared to that in the control experiment, the normalized fluxes at the optimal concentrations of MA was mitigated by 21%, and the amount of secreted biomass was reduced by nearly 50%. The two selected PhACs exacerbated biofouling and diminished the effects of the inhibitor on biofouling control. The rejections of CBZ and SMZ showed similar trends of first decreasing and then increasing during the 48-h dynamic biofouling experiment. The solution-dilution effect led to higher rejection of PhACs at the initial stage; then, the concentration polarization caused by the biofilms reduced the rejections of the two PhACs; subsequently, steric hindrance played a dominant role, resulting in an increase of the rejection.

中文翻译：

---

基于喹诺酮假单胞菌信号的正渗透膜群体淬灭去除药物的抗生物污染行为

摘要 在这项研究中，基于假单胞菌喹诺酮信号 (PQS) 的群体淬灭 (QQ) 对生物污垢控制的影响和减轻的生物污垢对药物活性化合物 (PhAC)，即卡马西平 (CBZ) 和磺胺甲恶唑 (SMZ) 的排斥反应的影响。系统地研究了渗透（FO）。结果表明，邻氨基苯甲酸甲酯 (MA) 是 PQS 途径的抑制剂，可有效减轻生物污垢。与对照实验相比，最佳MA浓度下的归一化通量降低了21%，分泌的生物量减少了近50%。两种选定的 PhAC 加剧了生物污垢并减弱了抑制剂对生物污垢控制的影响。在 48 小时动态生物污垢实验中，CBZ 和 SMZ 的去除率显示出相似的先减少后增加的趋势。溶液稀释效应导致初始阶段对 PhAC 的排斥率更高；然后，由生物膜引起的浓度极化降低了两种 PhAC 的排斥反应；随后，位阻占主导地位，导致排斥增加。