当前位置: X-MOL 学术J. Hazard. Mater. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Polystyrene microplastics induced male reproductive toxicity in mice.
Journal of Hazardous Materials ( IF 12.2 ) Pub Date : 2020-07-07 , DOI: 10.1016/j.jhazmat.2020.123430
Haibo Jin 1 , Tan Ma 1 , Xiaoxuan Sha 1 , Zhenyu Liu 1 , Yuan Zhou 1 , Xiannan Meng 1 , Yabing Chen 1 , Xiaodong Han 1 , Jie Ding 1
Affiliation  

Microplastics (MPs) have become hazardous materials, which have aroused widespread concern about their potential toxicity. However, the effects of MPs on reproductive systems in mammals are still ambiguous. In this study, the toxic effects of polystyrene MPs (PS-MPs) in male reproduction of mice were investigated. The results indicated that after exposure for 24 h, 4 μm and 10 μm PS-MPs accumulated in the testis of mice. Meanwhile, 0.5 μm, 4 μm, and 10 μm PS-MPs could enter into three kinds of testicular cells in vitro. In addition, sperm quality and testosterone level of mice were declined after exposure to 0.5 μm, 4 μm, and 10 μm PS-MPs for 28 days. H&E staining showed that spermatogenic cells abscissed and arranged disorderly, and multinucleated gonocytes occurred in the seminiferous tubule. Moreover, PS-MPs induced testicular inflammation and the disruption of blood-testis barrier. In summary, this study demonstrated that PS-MPs induced male reproductive dysfunctions in mice, which provided new insights into the toxicity of MPs in mammals.



中文翻译:

聚苯乙烯微塑料可诱导小鼠雄性生殖毒性。

微塑料(MPs)已成为危险材料,引起了人们对其潜在毒性的广泛关注。但是,MP对哺乳动物生殖系统的影响仍然不明确。在这项研究中,研究了聚苯乙烯MP(PS-MP)对小鼠雄性生殖的毒性作用。结果表明,暴露24 h后,小鼠睾丸中积累了4μm和10μmPS-MP。同时,0.5μm,4μm和10μmPS-MPs可以体外进入三种睾丸细胞。此外,小鼠的精子质量和睾丸激素水平在暴露于0.5μm,4μm和10μmPS-MP 28天后下降。H&E染色显示生精细胞脱落和排列紊乱,生精小管中出现多核性腺细胞。此外,PS-MPs引起睾丸发炎并破坏血液-睾丸屏障。总而言之,这项研究表明PS-MPs在小鼠中诱发了雄性生殖功能障碍,这为MPs在哺乳动物中的毒性提供了新的见解。

更新日期:2020-07-10
down
wechat
bug