The study investigated the polyphenol of Coreopsis tinctoria buds extract (CTBE) and its protective effects on cognitive dysfunction and brain damage induced by d-galactose in mice. Three polyphenols and nine flavonoids were characterized by UPLC/Q-TOF-MS, with major components as flavanomarein (13.644 mg/g dry weight) and marein (13.387 mg/g dry weight). Results showed CTBE significantly improved the learning, memory, and cognitive abilities and brain index of aging mice. Besides, CTBE reduced the content of malondialdehyde while increased the activity of glutathione peroxidase and superoxide dismutase and the the total antioxidants in brain. CTBE reversed the abnormality of Ach level, AChE activity, and hippocampus changes in aging mice. Therefore, CTBE, as a novel nutraceutical, could attenuate the cognitive damage and improve parameters related to brain senescence, partly by reducing the oxidative stress and hippocampal damage.

该研究研究了金鸡菊芽提取物（CTBE）中的多酚及其对d-半乳糖诱导的小鼠认知功能障碍和脑损伤的保护作用。通过UPLC / Q-TOF-MS对三种多酚和九种类黄酮进行了表征，主要成分为黄烷果胶（干重13.644 mg / g）和马来素（干重13.387 mg / g）。结果表明，CTBE可以显着改善衰老小鼠的学习，记忆，认知能力和脑指数。此外，CTBE降低了丙二醛的含量，同时增加了谷胱甘肽过氧化物酶和超氧化物歧化酶的活性以及脑中总抗氧化剂的含量。CTBE可以逆转衰老小鼠的Ach水平，AChE活性和海马变化异常。因此，CTBE作为一种新型的营养保健品，