Ozonation can be used as a polishing treatment for degrading low-concentration pharmaceutical compounds recalcitrant to biological treatment, when large amounts of biodegradable organics have been previously removed by biological processes. Nevertheless, a systematic investigation has not yet been carried out for the coupled MBR + O₃ process through an experimental design approach. Thereby, the purpose of this study is to evaluate the performance of different processes (membrane bioreactor-MBR, ozonation; and integrated MBR + O₃) for removing the antibiotic sulfadiazine (SDZ) from a synthetic wastewater matrix of industrial interest. The MBR behavior was monitored over seven months for different parameters (pH, temperature, permeate flow, transmembrane pressure, biological oxygen demand-BOD₅, chemical oxygen demand-COD, total organic carbon-TOC, solids, and SDZ concentration). Additionally, the amount of SDZ sorbed onto the sludge was characterized, an issue which is scarcely addressed in most research works. Ozonation experiments were conducted in batch mode in a 2-L glass reactor provided with openings for gas flow. For the MBR + O₃ process, the effects of gas flow rate (0.1–1.5 L min⁻¹) and inlet ozone concentration (4–12 mg L⁻¹) on SDZ removal from the MBR permeate were systematically assessed using a Doehlert experimental design and response surface methodology. The results indicated that the MBR system showed good performance regarding organic matter removal efficiency, evaluated in terms of BOD₅ (91.5%), COD (93.1%) and TOC (96.3%). In contrast, SDZ was partially removed (33%) by the MBR; in that case, the results indicated that the antibiotic was moderately removed with the sludge and partially biodegraded. In turn, the MBR + O₃ system showed excellent performance for removing SDZ (100%), TOC (97%), BOD₅ (94%) and COD (97%). The statistical analysis confirmed that the influence of ozone gas flow rate upon the SDZ removal rate was more important than that exhibited by inlet ozone concentration. Therefore, coupling MBR and ozone can be considered a promising alternative for point source treatment of antibiotic production wastewater.

当先前已通过生物学方法除去了大量可生物降解的有机物时，臭氧化可用作将难降解的低浓度药物化合物降解为生物处理的抛光处理。但是，尚未通过实验设计方法对MBR + O ₃偶联工艺进行系统的研究。因此，本研究的目的是评估不同过程的性能（膜生物反应器-MBR，臭氧化；以及集成的MBR + O ₃）从工业上感兴趣的合成废水基质中去除抗生素磺胺嘧啶（SDZ）。在七个月内对不同参数（pH，温度，渗透液流量，跨膜压力，生物需氧量-BOD ₅，化学需氧量-COD，总有机碳-TOC，固体和SDZ浓度）的MBR行为进行了监测。另外，表征了污泥中吸附的SDZ的量，这在大多数研究工作中都很少解决。在具有气孔的2-L玻璃反应器中以间歇模式进行臭氧化实验。对于MBR + O ₃工艺，气体流速（0.1–1.5 L min ^-1）和入口臭氧浓度（4-12 mg L ^{-1）的影响}使用Doehlert实验设计和响应面方法系统地评估了SDZ从MBR渗透物中的去除率。结果表明，MBR系统在有机物去除效率方面表现出良好的性能，根据BOD ₅（91.5％），COD（93.1％）和TOC（96.3％）进行了评估。相比之下，MBR部分去除了SDZ（33％）。在这种情况下，结果表明，该污泥可适度去除抗生素，并部分生物降解。反过来，MBR + O ₃系统表现出优异的去除SDZ（100％），TOC（97％）和BOD _{5的性能。}（94％）和COD（97％）。统计分析证实，臭氧气体流速对SDZ去除率的影响比入口臭氧浓度所显示的影响更重要。因此，将MBR和臭氧耦合可以视为抗生素生产废水的点源处理的有前途的替代方法。