Anticoagulant rodenticides are widely used for rodent control in agricultural and urban settings. Their intense use can sometimes result in accidental exposure and even poisoning of livestock. Can milk, eggs or meat derived from such accidently exposed animals be consumed by humans? Data on the pharmacokinetics of chlorophacinone in milk of accidently exposed ewes were used to estimate the risk associated with its consumption. Three days after accidental ingestion, chlorophacinone was detected in plasma of 18 ewes, with concentrations exceeding 100 ng/mL in 11 animals. Chlorophacinone was detected in milk on day 2 post-exposure and remained quantifiable for at least 7 days in milk of these 11 ewes. Concentrations in milk were much lower than in plasma and decreased quickly (mean half-life of 2 days). This study demonstrated dose-dependent mammary transfer of ingested chlorophacinone. Variation in prothrombin time (PT) on Day 3 suggested that some of the ewes that ingested chlorophacinone may have been adversely affected, but PT did not facilitate estimation of the quantity of chlorophacinone consumed. Using safety factors described in the literature, consumption of dairy products derived from these ewes after a one-week withdrawal period would pose low risk to consumers.

抗凝杀鼠剂广泛用于农业和城市环境中的灭鼠。过度使用它们有时可能会导致意外接触甚至牲畜中毒。从这种意外接触的动物中提取的牛奶，鸡蛋或肉类可以被人类食用吗？意外接触母羊的牛奶中氯霉素的药代动力学数据被用来估计与其食用有关的风险。意外摄入三天后，在11头母羊的血浆中检测到氯霉素，其浓度超过100 ng / mL。暴露后第2天在牛奶中检出了氯霉素酮，在这11头母羊的牛奶中，至少可定量检测7天。牛奶中的浓度远低于血浆中的浓度，并且迅速降低（平均半衰期为2天）。这项研究证明了摄入的氯霉素的剂量依赖性乳腺转移。第3天凝血酶原时间（PT）的变化表明，某些摄入了氯霉素的母羊可能受到了不利影响，但PT不利于估计所消耗的氯霉素的量。使用文献中描述的安全因素，在一周的停药期后食用源自这些母羊的乳制品将对消费者构成低风险。