Solid tumors reside in harsh tumor microenvironments (TMEs) together with various stromal cell types. During tumor progression and metastasis, both tumor and stromal cells undergo rapid metabolic adaptations. Tumor cells metabolically coordinate or compete with their “neighbors” to maintain biosynthetic and bioenergetic demands while escaping immunosurveillance or therapeutic interventions. Here, we provide an update on metabolic communication between tumor cells and heterogeneous stromal components in primary and metastatic TMEs and discuss emerging strategies to target metabolic communications for improved cancer treatments.

中文翻译：

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癌细胞不会单独生活：肿瘤微环境内的代谢交流。

实体瘤与各种基质细胞类型一起生活在恶劣的肿瘤微环境（TME）中。在肿瘤进展和转移期间，肿瘤和基质细胞均经历快速的代谢适应。肿瘤细胞通过代谢协调或与其“邻居”竞争，以维持生物合成和生物能量需求，同时逃避免疫监测或治疗干预。在这里，我们提供了肿瘤细胞与原发性和转移性TMEs中异质基质成分之间的代谢通讯的最新信息，并讨论了针对代谢通讯以改善癌症治疗的新兴策略。