In this study, eighteen heptamethine dyes were synthesised and their antifungal activities were evaluated against three clinically relevant yeast species.. The eighteen dyes were placed within classes based on their core subunit i.e. 2,3,3-trimethylindolenine (5a-f), 1,1,2-trimethyl-1H-benzo[e]indole (6a-f), or 2-methylbenzothiazole (7a-f). The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections. This opens up the opportunity for further optimisation and investigation of this class compounds for potential antifungal treatment.

在这项研究中，合成了十八种七甲胺染料，并针对三种临床相关的酵母菌种评估了它们的抗真菌活性。十八种染料根据其核心亚基即2,3,3-三甲基吲哚啉（5a-f），1 1,2,3-三甲基-1 H-苯并[ e ]吲哚（6a-f）或2-甲基苯并噻唑（7a-f）。本文呈现的结果暗示了三族花菁染料，特别是化合物5a-f，显示出作为治疗白色念珠菌感染的选择性支架的高潜力。这为进一步优化和研究此类化合物进行潜在的抗真菌治疗提供了机会。