Skin wounds, especially chronic wounds such as pressure and diabetic ulcers, are posing a huge threat to healthcare systems worldwide. Thus, novel strategies to realize effective wound therapy are nowadays extremely needed. Herein, we are the first to report a combination therapy of electric stimulation and heat for wound healing just using a facile piezoelectric and photothermal dual functional film. The film, name as CM@DA, is simply fabricated by coating polydopamine on a chitosan film. CM@DA generates electric voltages under mechanical pressure and shows photothermal effect with irradiation of near-infra red (NIR) light. In vivo experiment with rat full-thickness wound model validates that CM@DA with NIR can effectively promote wound regeneration due to the generation of electric stimulation and heat on wounds. The healing mechanism of CM@DA is further investigated, and the result demonstrates that CM@DA enhances wound healing through a pathway in which heat shock protein 90 (Hsp90) and hypoxia-inducible factor 1α (HIF-1α) participate. These results indicate that CM@DA is a promising wound dressing candidate for clinical application in the future.

皮肤伤口，特别是慢性伤口，例如压力和糖尿病性溃疡，对全球医疗系统构成了巨大威胁。因此，当今迫切需要实现有效伤口治疗的新颖策略。在本文中，我们是第一个报告仅使用简便的压电和光热双重功能膜将电刺激和热结合用于伤口愈合的疗法。该膜名为CM @ DA，是通过将聚多巴胺涂覆在壳聚糖膜上而简单制造的。CM @ DA在机械压力下产生电压，并通过照射近红外（NIR）光显示光热效应。体内用大鼠全层伤口模型进行的实验证明，由于电刺激和伤口产生热量，带有NIR的CM @ DA可有效促进伤口再生。进一步研究了CM @ DA的愈合机制，结果表明CM @ DA通过热休克蛋白90（Hsp90）和缺氧诱导因子1α（HIF-1α）参与的途径促进伤口愈合。这些结果表明，CM @ DA在未来的临床应用中是有希望的伤口敷料候选者。