Abstract

A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized. The solid form was prepared by liquid assisted grinding, slurry and crystallization methods. The cocrystal was characterized by powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and structure determined by single crystal X-ray diffraction, the hydrogen bonds formed into fish bone structure along the [010] direction and all the molecules packed into 3D layer structure along a axis. After formation of cocrystal, the solubility of diosgenin was improved, and the solubility value in 0.2% SDS solution was approximately 1.5 times as large as that of the parent material.

Graphic Abstract

中文翻译：

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2：1薯gen皂苷元-哌嗪共晶体的晶体结构，稳定性和溶解性评估。

摘要

成功合成了薯os皂苷元与哌嗪的2：1化学计量比的共晶体。通过液体辅助研磨，淤浆和结晶方法制备固体形式。通过粉末X射线衍射，差示扫描量热法，热重分析，傅里叶变换红外光谱法和通过单晶X射线衍射确定的结构表征共晶体，氢键沿[010]方向形成鱼骨结构，所有分子沿轴堆积成3D层结构。共晶形成后，薯os皂苷元的溶解度得到改善，在0.2％SDS溶液中的溶解度值约为母体材料的1.5倍。

图形摘要