Previous studies exploring associations between statin use and risk of multiple myeloma (MM) showed inconsistent results. We searched for articles published in English in databases (PubMed, Web of Science, EMBASE, Medline, and Google Scholar) before October 2019. The multivariate odds ratio (OR)/relative risk (RR) and 95% confidence intervals (CI) were computed to explore associations between statin use and risk of MM. The study indicated that statin users showed significantly lower risks of MM with a random effects model (OR/RR = 0.77, 95% CI 0.63 to 0.95, I² = 63.1%, p for Q test = 0.001). Subgroup analyses showed that statin users showed significantly lower risks of MM in Caucasian populations with a fixed effects model (OR/RR = 0.72, 95% CI 0.59 to 0.88, I² = 43.5%, p for Q test = 0.060), whereas no significant association was shown between statin use and risks of MM in Asian populations with a random effects model. Additionally, Subgroup analyses showed that statin users showed significantly lower risks of MM in cohort studies with a fixed effects model (RR = 0.83, 95% CI 0.74 to 0.93, I² = 0.0%, p for Q test = 0.429), whereas no significant association was shown between statin use and risks of MM in case-control studies with a random effects model. In conclusion, the present study indicated that statin use might be a protective factor for MM incidence. However, the relationship between statin use and MM risk requires repeated and large prospective studies to be verified.

先前的研究探讨了他汀类药物的使用与多发性骨髓瘤（MM）风险之间的关系，但结果不一致。我们在2019年10月之前在数据库（PubMed，Web of Science，EMBASE，Medline和Google Scholar）中搜索了以英语发表的文章。多元优势比（OR）/相对风险（RR）和95％置信区间（CI）为计算以探讨他汀类药物使用与MM风险之间的关联。研究表明，他汀类药物使用者在随机效应模型中显示出较低的MM风险（OR / RR = 0.77，95％CI 0.63至0.95，I ²  = 63.1％，p为Q测试= 0.001）。亚组分析表明，他汀类药物的用户显示在高加索人群MM的显著风险较低具有固定效应模型（OR / RR = 0.72，95％CI 0.59至0.88，我²  = 43.5％，p为Q测试= 0.060），而没有随机效应模型显示，他汀类药物的使用与亚洲人群MM风险之间存在显着相关性。此外，亚组分析显示，在具有固定效应模型的队列研究中，他汀类药物使用者显示出的MM风险显着降低（RR = 0.83，95％CI 0.74至0.93，I ²  = 0.0％，p为Q检验= 0.429），而在使用随机效应模型的病例对照研究中，他汀类药物的使用与MM的风险之间没有显着相关性。总之，本研究表明他汀类药物的使用可能是MM发病的保护因素。但是，他汀类药物的使用与MM风险之间的关系需要反复和大量的前瞻性研究进行验证。