A practical wearable brain PET scanner capable of dynamic neuroimaging during free bodily movement will enable potential breakthrough basic neuroscience studies and help develop imaging-based neurological diagnoses and treatments. Weight, brain coverage, and sensitivity are three fundamental technical obstacles in the development of Fully Wearable High-Performance (FWHP) brain PET scanners. The purpose of this study is to investigate the feasibility of building a FWHP brain PET using a limited volume of lutetium–yttrium oxyorthosilicate (LYSO) scintillator crystals. Six scanners, consisted of the same volume (2.66 kg) of LYSO scintillators with combinations of 2 different crystal pitches (3 mm and 1.5 mm) and 3 different crystal lengths (20 mm, 10 mm, and 5 mm), were simulated. The performances of the six scanners were assessed and compared with Siemen’s HRRT brain PET and mCT whole-body PET, in terms of aperture, axial field of views (AFOV), sensitivity, spatial resolution, cou...

中文翻译：

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完全可佩戴的高性能大脑PET在自由运动中进行神经成像的设计研究

实用的可穿戴式大脑PET扫描仪能够在自由运动期间进行动态神经成像，这将使潜在的突破性基础神经科学研究成为可能，并有助于发展基于成像的神经系统诊断和治疗方法。重量，大脑覆盖范围和敏感性是完全可穿戴高性能（FWHP）脑部PET扫描仪开发中的三个基本技术障碍。这项研究的目的是研究使用有限体积的-钇正硅酸（（LYSO）闪烁体晶体构建FWHP脑PET的可行性。模拟了六个由相同体积（2.66 kg）的LYSO闪烁体组成的扫描仪，该扫描仪具有2种不同的晶体间距（3 mm和1.5 mm）和3种不同的晶体长度（20 mm，10 mm和5 mm）的组合。