Mutational signatures can reveal the history of mutagenic processes that cells were exposed to before and during tumorigenesis. We expect that as-yet-undiscovered mutational processes will shed further light on mutagenesis leading to carcinogenesis. With this in mind, we analyzed the mutational spectra of 36 Asian oral squamous cell carcinomas. The mutational spectra of two samples from patients who presented with oral bacterial infections showed novel mutational signatures. One of these novel signatures, SBS_AⁿT, is characterized by a preponderance of thymine mutations, strong transcriptional strand bias, and enrichment for adenines in the 4 bp 5′ of mutation sites. The mutational signature described in this manuscript was shown to be caused by colibactin, a bacterial mutagen produced by E. coli carrying the pks-island. Examination of publicly available sequencing data revealed SBS_AⁿT in 25 tumors from several mucosal tissue types, expanding the list of tissues in which this mutational signature is observed.

中文翻译：

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在亚洲口腔鳞状细胞癌和其他黏膜肿瘤类型中与大肠菌素相关的突变特征的表征。

突变特征可以揭示肿瘤发生之前和过程中细胞所经历的诱变过程的历史。我们期望尚未发现的突变过程将进一步阐明导致致癌作用的诱变。考虑到这一点，我们分析了36种亚洲口腔鳞状细胞癌的突变谱。来自患有口腔细菌感染的患者的两个样品的突变谱显示出新的突变特征。这些新颖的特征之一，SBS_A ⁿ T，以胸腺嘧啶突变占优势，强转录链偏向和突变位点4 bp 5'中腺嘌呤的富集为特征。该手稿中描述的突变特征表明是由大肠杆菌产生的细菌诱变菌杆菌素引起的携带pks -island。对公开可用测序数据的检查显示，SBS_A ⁿ T存在于来自几种粘膜组织类型的25个肿瘤中，从而扩大了观察到这种突变特征的组织列表。