The extracellular matrix (ECM) offers a structural basis for regulating cell functions while also acting as a collection point for bioactive molecules and connective tissue cells. To perform pathological functions under a pathological condition, the involved cells need to regulate the ECM to support their altered functions. This is particularly common in the development of cancer. The ECM has been recognized as a key driver of cancer development and progression, and ECM remodeling occurs at all stages of cancer progression. Thus, cancer cells need to change the ECM to support relevant cell surface adhesion receptor–mediated cell functions. In this context, it is interesting to examine how cancer cells regulate ECM remodeling, which is critical to tumor malignancy and metastatic progression. Here, we review how the cell surface adhesion receptor, syndecan, regulates ECM remodeling as cancer progresses, and explore how this can help us better understand ECM remodeling under these pathological conditions

细胞外基质（ECM）为调节细胞功能提供了结构基础，同时也充当生物活性分子和结缔组织细胞的收集点。为了在病理条件下发挥病理功能，相关细胞需要调节 ECM 以支持其改变的功能。这在癌症的发展中尤其常见。ECM 已被认为是癌症发生和进展的关键驱动因素，ECM 重塑发生在癌症进展的所有阶段。因此，癌细胞需要改变 ECM 以支持相关的细胞表面粘附受体介导的细胞功能。在这种背景下，研究癌细胞如何调节 ECM 重塑是很有趣的，这对于肿瘤恶性肿瘤和转移进展至关重要。在这里，我们回顾了细胞表面粘附受体 Syndecan 如何在癌症进展过程中调节 ECM 重塑，并探讨这如何帮助我们更好地了解这些病理条件下的 ECM 重塑