Small leucine rich proteoglycans (SLRPs), including Biglycan, have key roles in many organ and tissue systems. The goal of this article is to review the function of Biglycan and other related SLRPs in mineralizing tissues of the skeleton. The review is divided into sections that include Biglycan’s role in structural biology, signaling, craniofacial and long bone homeostasis, remodeled skeletal tissues, and in human genetics. While many cell types in the skeleton are now known to be affected by Biglycan, there are still unanswered questions about its mechanism of action(s).

中文翻译：

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骨架中的 Biglycan。

小的富含亮氨酸的蛋白聚糖 (SLRP)，包括 Biglycan，在许多器官和组织系统中具有关键作用。本文的目的是回顾 Biglycan 和其他相关 SLRP 在骨骼组织矿化中的功能。该综述分为几个部分，其中包括 Biglycan 在结构生物学、信号传导、颅面和长骨稳态、重塑骨骼组织以及人类遗传学中的作用。虽然现在已知骨骼中的许多细胞类型受到 Biglycan 的影响，但关于其作用机制仍然存在未解决的问题。