Background: Vast increases in life expectancy over the last century have led to shifts in population demographics and the emergence of a largely aged population, globally. This has led to a need to understand neurobiological changes associated with healthy aging. Studies on age-related changes in functional connectivity networks have largely been cross-sectional and focused on the default mode network (DMN). The current study investigated longitudinal changes in functional connectivity in multiple resting-state networks over 4 years of aging in cognitively normal older adults.

中文翻译：

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健康老龄化期间静息状态功能磁共振成像功能连接网络变化的纵向研究。

背景：上个世纪预期寿命的大幅增加导致全球人口结构的变化和老龄化人口的出现。这导致需要了解与健康衰老相关的神经生物学变化。关于功能连接网络中与年龄相关的变化的研究主要是横断面的，并且集中在默认模式网络 (DMN) 上。目前的研究调查了认知正常的老年人在 4 年衰老过程中多个静息状态网络中功能连接的纵向变化。