Vaccination is one of the most effective and cost-efficient methods for protecting people with multiple sclerosis (MS) from infections. However, use of vaccines has often been problematic because of misguided concerns that they may exacerbate the disease and/or that some disease-modifying therapies may influence the immune response to immunisations and/or their safety. People with MS risk higher morbidity and mortality from vaccine-preventable infections. It is, therefore, important to address any patient’s reluctance to accept vaccination and to provide clear guidance for clinicians on which vaccinations to consider proactively. We have reviewed the current literature and provide recommendations regarding vaccines in adults with MS, including specific advice regarding vaccination safety in patients receiving—or going to receive—disease-modifying therapies, vaccination during pregnancy, pretravel counselling and patient education.

中文翻译：

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通过疫苗接种保护多发性硬化症患者

接种疫苗是保护多发性硬化症 (MS) 患者免受感染的最有效和最具成本效益的方法之一。然而，由于错误地担心疫苗可能会加剧疾病和/或某些缓解疾病的疗法可能会影响对免疫的免疫反应和/或其安全性，因此使用疫苗往往存在问题。MS 患者因疫苗可预防的感染而面临更高的发病率和死亡率。因此，重要的是要解决任何患者不愿意接受疫苗接种的问题，并为临床医生提供明确的指导，让他们主动考虑接种哪些疫苗。我们回顾了当前的文献并提供了关于成人 MS 疫苗的建议，