Amino-Functionalized Mesoporous Silica Nanoparticle-Encapsulated Octahedral Organoruthenium Complex as an Efficient Platform for Combatting Cancer.,Inorganic Chemistry

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Amino-Functionalized Mesoporous Silica Nanoparticle-Encapsulated Octahedral Organoruthenium Complex as an Efficient Platform for Combatting Cancer.
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2020-07-06 , DOI: 10.1021/acs.inorgchem.0c01436
Marina Martínez-Carmona ₁ , Quy P Ho _{2,

3} , Jérémy Morand ₁ , Ana García _{4,

5} , Enrique Ortega ₆ , Luiza C S Erthal _{2,

3} , Eduardo Ruiz-Hernandez _{2,

3} , M Dolores Santana ₆ , José Ruiz ₆ , Maria Vallet-Regí _{4,

5} , Yurii K Gun'ko ₁

Affiliation

In the process of synthesis of a new drug, as important as the drug itself is the formulation used, because the same compound can present a very different efficacy depending on how it is administered. In this work, we demonstrate how the antitumor capacity of a new octahedral organoruthenium complex, [Ru(ppy-CHO)(phen)₂][PF₆] is affected by its encapsulation in different types of mesoporous silica nanoparticles. The interactions between the Ru complex and the silica matrix and how these interactions are affected at two different pHs (7.4 and 5.4, mimicking physiological and endolysosomal acidic conditions, respectively) have been studied. The encapsulation has also been shown to affect the induction of apoptosis and necrosis and progression of the cell cycle compared to the free drug. The encapsulation of the Ru complex in nanoparticles functionalized with amino groups produced very high anticancer activity in cancer cells in vitro, especially against U87 glioblastoma cells, favoring cellular internalization and significantly increasing the anticancer capacity of the initial non-encapsulated Ru complex.

中文翻译：

氨基官能化介孔二氧化硅纳米颗粒包裹的八面体有机钌复合物作为抗癌的有效平台。

在合成新药物的过程中，所用的制剂与药物本身一样重要，因为根据给药方式的不同，同一化合物可能会表现出非常不同的功效。在这项工作中，我们演示了新型八面体有机钌配合物[Ru（ppy-CHO）（phen）₂ ] [PF ₆）的抗肿瘤能力。其封装在不同类型的介孔二氧化硅纳米粒子中会受到影响。研究了Ru络合物与二氧化硅基质之间的相互作用以及在两种不同的pH值（分别为7.4和5.4，分别模拟生理和溶酶体酸性条件）下如何影响这些相互作用。与游离药物相比，该封装还显示出影响凋亡的诱导和坏死以及细胞周期的进展。Ru复合物在氨基官能化的纳米粒子中的封装在体外癌细胞中产生了很高的抗癌活性，尤其是针对U87胶质母细胞瘤细胞，有利于细胞内在化并显着提高了初始非封装Ru复合物的抗癌能力。

更新日期：2020-07-20

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