Objective. To investigate prognostic values of serum biomarkers of soluble intercellular adhesion molecule 1 (sICAM-1), macrophage migration inhibitor factor (MIF), interleukin 1β (IL-1β), and soluble urokinase plasminogen activator receptor (su-PAR) in patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). Methods. From August 2017 to November 2019, 122 consecutive IPF patients treated in our center were classified as stable IPF and AE-IPF based on the newly published international guidelines. Serum levels of four biomarkers at admission were measured by the enzyme-linked immunosorbent assay (ELISA). The primary endpoint was 3-month mortality. The log-rank test and logistic regression analysis were used to evaluate the effects of these biomarkers for survival in patients with AE-IPF. Cox proportional hazards analysis was performed to evaluate the prognostic values of serological biomarkers and clinical data. Results. Eighty-one patients were diagnosed with stable IPF, and 41 AE-IPF patients were enrolled in the study. Serum levels of sICAM-1 (), IL-1β (), MIF (), and su-PAR () in patients with IPF were significantly increased compared to those in healthy controls. All the four biomarkers were elevated in patients with AE-IPF compared to those with stable IPF. The 3-month mortality in AE-IPF was 56.1% (23/41). Increased levels of MIF () and IL-1β (>5 pg/mL, ) were independent risk factors for 3-month mortality in patients with AE-IPF. Conclusions. We showed the higher serum levels of IL-1β, and MIF had prognostic values for 3-month mortality in AE-IPF. This study provided a clue to promote our understanding in the pathogenesis of the disease.

中文翻译：

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sICAM-1、IL-1β、MIF 和 su-PAR 的血清学生物标志物与特发性肺纤维化急性加重中 3 个月死亡率的关联。

客观。探讨可溶性细胞间粘附分子 1 (sICAM-1)、巨噬细胞迁移抑制因子 (MIF)、白细胞介素 1 β (IL-1 β ) 和可溶性尿激酶纤溶酶原激活物受体 (su-PAR) 的血清生物标志物对患者的预后价值特发性肺纤维化（AE-IPF）急性加重。方法. 2017 年 8 月至 2019 年 11 月，我中心连续治疗的 122 例 IPF 患者根据新发布的国际指南分为稳定型 IPF 和 AE-IPF。通过酶联免疫吸附试验（ELISA）测量入院时四种生物标志物的血清水平。主要终点是 3 个月死亡率。对数秩检验和逻辑回归分析用于评估这些生物标志物对 AE-IPF 患者生存的影响。进行 Cox 比例风险分析以评估血清学生物标志物和临床数据的预后价值。结果。81 名患者被诊断为 IPF 稳定，41 名 AE-IPF 患者被纳入研究。sICAM-1 的血清水平 (), IL-1 β (), MIF ()和 su-PAR ()与健康对照组相比，IPF 患者显着增加。与稳定 IPF 患者相比，AE-IPF 患者的所有四种生物标志物均升高。AE-IPF 的 3 个月死亡率为 56.1% (23/41)。MIF 水平升高 ()和 IL-1 β (>5 pg/mL,)是 AE-IPF 患者 3 个月死亡率的独立危险因素。结论。我们显示了较高的血清 IL-1 β水平，并且 MIF 对 AE-IPF 的 3 个月死亡率具有预后价值。该研究为促进我们对该疾病发病机制的理解提供了线索。