¹⁸⁸Re and ¹⁸⁶Re are two applicable rhenium medical radioisotopes with complementary features that make them beneficial for different sizes of tumours. The aim of this study is to investigate ^188/186Re-HEDP efficacy as a cocktail by calculating absorbed radiation dose in human organs based on biodistribution data obtained by injecting it to normal rats. Three rats were sacrificed at different time intervals and the percentage of injected dose per gram of each organ was measured by direct counting from rat data. By calculating accumulated activities in each organ and extrapolating rat data to human data by the radiation dose assessment resource method and by using OLINDA/EXM software, the injected dose in various human organs was obtained. The calculated absorbed dose showed that the ^188/186Re-HEDP has noticeable properties that can be more helpful in comparison with using each of the rhenium radioisotopes separately.

中文翻译：

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基于OLINDA / EXM和大鼠分布数据的188 / 186RE-HEDP鸡尾酒人剂量估算。

¹⁸⁸ Re和¹⁸⁶ Re是两种适用的rh医学放射性同位素，具有互补的特征，使它们对不同大小的肿瘤均有益。这项研究的目的是调查^188/186通过将人体注射到正常大鼠中获得的生物分布数据来计算人体器官中的吸收辐射剂量，从而获得重HEDP鸡尾酒的功效。在不同的时间间隔处死三只大鼠，并通过直接从大鼠数据中计数来测量每克每个器官的注射剂量百分比。通过计算每个器官中的累积活动，并通过辐射剂量评估资源方法并使用OLINDA / EXM软件将大鼠数据外推至人体数据，从而获得了人体各个器官的注射剂量。计算出的吸收剂量表明^188/186 Re-HEDP具有显着的特性，与分别使用每种the放射性同位素相比，它可以提供更大的帮助。