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Monodisperse Hollow MnO2 with Biodegradability for Efficient Targeted Drug Delivery
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-07-06 , DOI: 10.1021/acsbiomaterials.0c00507 Mo Cheng 1 , Yan Yu 2 , Wending Huang 1 , Meng Fang 1 , Yong Chen 1 , Chunmeng Wang 1 , Weiluo Cai 1 , Shuyu Zhang 2 , Wenxing Wang 3 , Wangjun Yan 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-07-06 , DOI: 10.1021/acsbiomaterials.0c00507 Mo Cheng 1 , Yan Yu 2 , Wending Huang 1 , Meng Fang 1 , Yong Chen 1 , Chunmeng Wang 1 , Weiluo Cai 1 , Shuyu Zhang 2 , Wenxing Wang 3 , Wangjun Yan 1
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The development of new nanocarriers with desired degradability and targeted ability is of great significance for efficient drug delivery. In this work, a monodisperse hollow structured MnO2 (H-MnO2) with a mesoporous shell is prepared and functionalized for efficient targeted drug delivery. The highly monodisperse H-MnO2 with a uniform morphology was obtained by in situ growing MnO2 on solid silica nanoparticles and subsequently removing the silica core. Then, the H-MnO2 is successively modified with polyethylene glycol and targeted molecule folate (FA). The resultant H-MnO2-FA shows excellent colloidal stability and high drug-loading content (∼58.2%) of the antitumor drug doxorubicin hydrochloride (DOX). The H-MnO2-FA possesses acid-responsive T1-weighted magnetic resonance imaging ability. The pH-dependent biodegradation behavior of H-MnO2-FA is directly observed in vitro and confirmed by in vivo imaging, which is expected to favor the potential clearance of this hollow structured nanocarrier and eliminate its long-term toxicity. In addition, the DOX-loaded H-MnO2-FA also demonstrates excellent cancer cell-killing effect and tumor inhibition efficacy.
中文翻译：
具有生物降解能力的单分散空心MnO 2，可有效地靶向药物输送。
具有期望的可降解性和靶向能力的新型纳米载体的开发对于有效的药物递送具有重要意义。在这项工作中，制备具有中孔壳的单分散空心结构MnO 2（H-MnO 2）并对其进行功能化，以实现有效的靶向药物输送。通过在固体二氧化硅纳米颗粒上原位生长MnO 2并随后除去二氧化硅核，可以获得具有均匀形态的高度单分散的H-MnO 2。然后，用聚乙二醇和目标分子叶酸（FA）连续修饰H-MnO 2。生成的H-MnO 2-FA显示出优异的胶体稳定性和抗肿瘤药盐酸阿霉素（DOX）的高载药量（〜58.2％）。H-MnO 2 -FA具有酸响应性T 1加权磁共振成像能力。H-MnO 2 -FA的pH依赖性生物降解行为可以在体外直接观察到，并通过体内成像得到证实，这有望促进这种空心结构纳米载体的潜在清除并消除其长期毒性。另外，负载DOX的H-MnO 2 -FA还显示出优异的癌细胞杀伤作用和肿瘤抑制功效。
更新日期：2020-09-14
中文翻译：
具有生物降解能力的单分散空心MnO 2，可有效地靶向药物输送。
具有期望的可降解性和靶向能力的新型纳米载体的开发对于有效的药物递送具有重要意义。在这项工作中，制备具有中孔壳的单分散空心结构MnO 2（H-MnO 2）并对其进行功能化，以实现有效的靶向药物输送。通过在固体二氧化硅纳米颗粒上原位生长MnO 2并随后除去二氧化硅核，可以获得具有均匀形态的高度单分散的H-MnO 2。然后，用聚乙二醇和目标分子叶酸（FA）连续修饰H-MnO 2。生成的H-MnO 2-FA显示出优异的胶体稳定性和抗肿瘤药盐酸阿霉素（DOX）的高载药量（〜58.2％）。H-MnO 2 -FA具有酸响应性T 1加权磁共振成像能力。H-MnO 2 -FA的pH依赖性生物降解行为可以在体外直接观察到，并通过体内成像得到证实，这有望促进这种空心结构纳米载体的潜在清除并消除其长期毒性。另外，负载DOX的H-MnO 2 -FA还显示出优异的癌细胞杀伤作用和肿瘤抑制功效。
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