ABSTRACT This is the first study on antioxidant and antibacterial activity of essential oils of A. sylvestris and A. pancicii against the human pathogens. In the oil of A. sylvestris, the main compounds were limonene (75.3%) and α-pinene (9.6%), while in the oil of A. pancicii the main compounds were β-phellandrene (54.9%), α-pinene (14.5%) and α-phellandrene (4.05%). The results of ABTS have shown that antioxidant activity ranged between 1.48 and 2.07 mg VitC/g for 30 μL/mL of tested concentration. IC50 values in DPPH assay ranged between 59.895 and 149.498 mg/mL of tested concentrations. Antibacterial activity of the essential oils and antibiotics against pathogenic bacterial strains was investigated using microwell dilution method. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were in the ranges of MIC/MBC = 0.11/54.40 mg/mL and 0.10/48.20 mg/mL (respectively). When combined with antibiotics, the oils have exhibited synergism and may reduce the minimum effective dose of antibiotics required and minimize its side effects.

中文翻译：

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巴尔干半岛野生当归（伞形科）对人类致病菌的抗菌和抗氧化活性

摘要 本研究首次研究了樟子松（A. sylvestris）和松茸（A. pancicii）精油对人类病原体的抗氧化和抗菌活性。樟子松油中主要化合物为柠檬烯（75.3%）和α-蒎烯（9.6%），而松子油中主要化合物为β-水芹烯（54.9%）、α-蒎烯（ 14.5%) 和 α-水芹烯 (4.05%)。ABTS 的结果表明，对于 30 μL/mL 的测试浓度，抗氧化活性介于 1.48 和 2.07 mg VitC/g 之间。DPPH 测定中的 IC50 值范围在 59.895 和 149.498 毫克/毫升的测试浓度之间。使用微孔稀释法研究了精油和抗生素对致病细菌菌株的抗菌活性。最低抑菌浓度 (MIC) 和最低杀菌浓度 (MBC) 的范围分别为 MIC/MBC = 0.11/54.40 mg/mL 和 0.10/48.20 mg/mL。当与抗生素结合使用时，这些油表现出协同作用，可以减少所需抗生素的最小有效剂量并最大限度地减少其副作用。