Abstract

With the outbreak caused by the severe acute respiratory syndrome coronavirus (COVID-19), people’s health and existing economies on a global scale are seriously threatened. Currently, most of the countries all over the world are studying extensively to better understand the antimalarial chloroquine (CQ) and hydroxychloroquine (HCQ) for therapeutic purposes due to the COVID-19 outbreak. However, CQ and HCQ can have serious side effects, from psychiatric effects to sudden death. Therefore, a faster and more effective detection method is needed to monitor drug concentrations. In this review, a large study was conducted on the detection techniques and quantitative determination methods of CQ and its related metabolites. In this review, chromatography, electrophoresis, electroanalytical, spectroscopic, and immunological methods for CQ and related metabolites are discussed extensively. It is hoped that a better understanding of the CQ used for therapeutic purposes in the COVID-19 outbreak will be provided.

摘要

随着严重急性呼吸系统综合症冠状病毒（COVID-19）的爆发，全球范围内的人民健康和现有经济受到严重威胁。目前，世界上大多数国家都在广泛研究，以更好地了解抗疟药氯喹 (CQ) 和羟氯喹 (HCQ) 在 COVID-19 爆发后的治疗用途。然而，CQ 和 HCQ 可能会产生严重的副作用，从精神影响到猝死。因此，需要一种更快、更有效的检测方法来监测药物浓度。本综述对CQ及其相关代谢物的检测技术和定量测定方法进行了大规模研究。在这篇综述中，色谱、电泳、电分析、光谱、广泛讨论了 CQ 和相关代谢物的免疫学方法。希望能够更好地了解在 COVID-19 爆发中用于治疗目的的 CQ。