Abstract An analytical method for the quantification of anticancer agents such as imatinib, sorafenib, gefitinib and bosutinib using conductometry was developed. Each drug solution was mixed with measured concentration of metal ion (Cu2+) solution resulting in drug–metal ion complexation in the titration cell. Conductance was progressively decreased on addition of the analyte solution up to a point of maximum reduction, that is, the end point. Corrected conductance values were calculated from the observed conductance and used to plot a graph against the volume of drug solution added. No interferences were observed from blank and placebo as they gave no clear inflection in the conductivity during titration. The precision and the accuracy of the developed method was established by the analysis of quality control samples; %RSD of corrected conductance values <2% and recovery results within 100 ± 2% were achieved. The calibration graphs obtained were linear over the concentrations 1.0–1.4 mM for all the drugs (R 2 > 0.99). The drugs were successfully analyzed in their respective dosage forms prepared in-house. The method has offered easier, faster and cost-effective analysis of the selected drugs and can be used for routine determinations in the quality control laboratories. More importantly, it is an environmental friendly procedure, as no organic solvent was used throughout the analysis.

中文翻译：

---

药物-金属离子相互作用原理在伊马替尼、索拉非尼、吉非替尼和博舒替尼电导测定中的应用

摘要 开发了一种使用电导测定法对伊马替尼、索拉非尼、吉非替尼和博舒替尼等抗癌药物进行定量的分析方法。每种药物溶液都与测量浓度的金属离子 (Cu2+) 溶液混合，导致滴定池中的药物-金属离子络合。随着分析物溶液的加入，电导逐渐降低，直至达到最大降低点，即终点。根据观察到的电导计算校正的电导值，并用于绘制与添加的药物溶液体积的关系图。空白和安慰剂没有观察到干扰，因为它们在滴定过程中没有明显的电导率变化。所开发方法的精密度和准确度是通过对质控样品的分析来确定的；获得了校正电导值 <2% 的 %RSD 和 100 ± 2% 内的回收率结果。对于所有药物，获得的校准图在 1.0–1.4 mM 的浓度范围内呈线性（R 2 > 0.99）。在内部制备的各自剂型中成功地分析了这些药物。该方法提供了对所选药物的更简单、更快和成本效益的分析，可用于质量控制实验室的常规测定。更重要的是，它是一种环保程序，因为在整个分析过程中没有使用有机溶剂。该方法提供了对所选药物的更简单、更快和成本效益的分析，可用于质量控制实验室的常规测定。更重要的是，它是一种环保程序，因为在整个分析过程中没有使用有机溶剂。该方法提供了对所选药物的更简单、更快和成本效益的分析，可用于质量控制实验室的常规测定。更重要的是，它是一种环保程序，因为在整个分析过程中没有使用有机溶剂。