Comparison of commercial surface-enhanced Raman spectroscopy substrates for the analysis of cocaine,Drug Testing and Analysis

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Comparison of commercial surface-enhanced Raman spectroscopy substrates for the analysis of cocaine
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-07-05 , DOI: 10.1002/dta.2894
Rhiannon Alder _{1,

2} , Linda Xiao ₁ , Shanlin Fu _{1,

2}

Affiliation

The use of illicit drugs across the world causes issues for users, healthcare workers and the public. Therefore, rapid and reliable onsite testing methods to detect these drugs are required. In this study, seven commercial surface-enhanced Raman spectroscopy (SERS) substrates A–G were compared for the analysis of cocaine. These substrates were compared using scanning electron microscopy to study the surface structure and Raman spectroscopy and to determine if there was any enhancement of the cocaine bands. Substrate B provided the best enhancement of known cocaine vibrational bands, allowing the detection down to concentrations of 1 ng/mL in standards and 10 ng/mL extracted from the oral fluid. The results showed that SERS is an ideal method for future rapid onsite analysis of illicit drugs in oral fluid. Commercial SERS substrates were compared for the analysis of cocaine. Substrate B provided the best result and was further tested with lower concentrations and extracts from the oral fluid. The application to oral fluid testing could prove useful for future onsite analysis.

中文翻译：

用于分析可卡因的商用表面增强拉曼光谱底物的比较

世界各地非法药物的使用给使用者、医护人员和公众带来了问题。因此，需要快速可靠的现场检测方法来检测这些药物。在这项研究中，对七种商用表面增强拉曼光谱 (SERS) 底物 A-G 进行了可卡因分析比较。使用扫描电子显微镜比较这些底物以研究表面结构和拉曼光谱并确定可卡因谱带是否有任何增强。底物 B 提供了已知可卡因振动带的最佳增强，允许检测到标准品中的 1 ng/mL 浓度和从口腔液中提取的 10 ng/mL 浓度。结果表明，SERS 是未来快速现场分析口腔液中违禁药物的理想方法。比较商业 SERS 底物以分析可卡因。底物 B 提供了最好的结果，并用较低浓度的口腔液和提取物进行了进一步测试。口腔液体测试的应用可能对未来的现场分析有用。

更新日期：2020-07-05

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