Rapid and convenient wound healing is crucial for reducing potential post‐traumatic wound complications. In this study, a temperature‐sensitive polymer of poly‐(HEMA‐co‐NIPAM) (PHN) was synthesized by free‐radical polymerization, in which the solution quickly underwent a sol–gel transition above 29°C, thus responding to a typical body temperature and facilitating wound sealing. PHN solution incorporated with copper ions (PHN‐Cu) not only exhibited excellent antibacterial properties, but also expedited wound closure and facilitated tissue angiogenesis. The in vivo and in vitro experiments showed that the PHN‐Cu had a higher wound closure rate and demonstrated an ability to promote skin tissue angiogenesis. Such a versatile, convenient aqueous solution could enable nonprofessionals to promptly treat wounds in a short time after injury, thus providing suitable conditions for later treatment, and can be used as a convenient method to clean wounds.

中文翻译：

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一种利用聚-(HEMA-co-NIPAM)/Cu2+溶液溶胶-凝胶转变来保护和愈合伤口的便捷方法。


快速、方便的伤口愈合对于减少潜在的创伤后伤口并发症至关重要。在这项研究中，通过自由基聚合合成了聚（HEMA-co-NIPAM）（PHN）的温度敏感聚合物，其中溶液在 29°C 以上快速经历溶胶-凝胶转变，从而响应典型体温并促进伤口密封。掺有铜离子（PHN-Cu）的 PHN 溶液不仅具有优异的抗菌性能，而且还能加速伤口闭合并促进组织血管生成。体内和体外实验表明，PHN-Cu具有较高的伤口闭合率，并具有促进皮肤组织血管生成的能力。这种多用途、方便的水溶液可以使非专业人员在受伤后短时间内迅速处理伤口，从而为后续治疗提供合适的条件，并且可以作为清洁伤口的便捷方法。