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Cadmium Induces Iron Deficiency Anemia through the Suppression of Iron Transport in the Duodenum
Toxicology Letters ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.toxlet.2020.07.005 Yasuyuki Fujiwara 1 , Jin-Yong Lee 2 , Hiroki Banno 2 , Shunji Imai 3 , Maki Tokumoto 2 , Tatsuya Hasegawa 4 , Yoshiyuki Seko 4 , Hisamitsu Nagase 5 , Masahiko Satoh 2
Toxicology Letters ( IF 2.9 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.toxlet.2020.07.005 Yasuyuki Fujiwara 1 , Jin-Yong Lee 2 , Hiroki Banno 2 , Shunji Imai 3 , Maki Tokumoto 2 , Tatsuya Hasegawa 4 , Yoshiyuki Seko 4 , Hisamitsu Nagase 5 , Masahiko Satoh 2
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Cadmium (Cd) is an environmental contaminant that triggers toxic effects in various tissues such as the kidney, liver, and lung. Cd can also cause abnormal iron metabolism, leading to anemia. Iron homeostasis is regulated by intestinal absorption. However, whether Cd affects the iron absorption pathway is unclear. We aimed to elucidate the relationship between the intestinal iron transporter system and Cd-induced iron deficiency anemia. C57BL/6 J female and male mice, 129/Sv female mice, and DBA/2 female mice were given a single oral dose of CdCl2 by gavage. After 3 or 24 h, Cd decreased serum iron concentrations and inhibited the expression of iron transport-related genes in the duodenum. In particular, Cd decreased the levels of divalent metal transporter 1 and ferroportin 1 in the duodenum. In addition, human colon carcinoma Caco-2 cells were treated with CdCl2. After 72 h, Cd decreased the expression of iron transport-related factors in Caco-2 cells with a pattern similar to that seen in the murine duodenum. These findings suggest that Cd inhibits iron absorption through direct suppression of iron transport in duodenal enterocytes and contributes to abnormal iron metabolism.
中文翻译：
镉通过抑制十二指肠中的铁转运导致缺铁性贫血
镉 (Cd) 是一种环境污染物，会在肾脏、肝脏和肺等各种组织中引发毒性作用。镉还能引起铁代谢异常，导致贫血。铁稳态受肠道吸收调节。然而，Cd 是否影响铁吸收途径尚不清楚。我们旨在阐明肠道铁转运系统与 Cd 引起的缺铁性贫血之间的关系。C57BL/6 J 雌性和雄性小鼠、129/Sv 雌性小鼠和 DBA/2 雌性小鼠通过管饲法给予单次口服剂量的 CdCl2。3 或 24 小时后，Cd 降低血清铁浓度并抑制十二指肠中铁转运相关基因的表达。特别是，Cd 降低了十二指肠中二价金属转运蛋白 1 和铁转运蛋白 1 的水平。此外，人结肠癌 Caco-2 细胞用 CdCl2 处理。72 小时后，Cd 降低 Caco-2 细胞中铁转运相关因子的表达，其模式类似于在鼠十二指肠中看到的模式。这些发现表明，Cd 通过直接抑制十二指肠肠细胞中的铁转运来抑制铁的吸收，并导致铁代谢异常。
更新日期：2020-10-01
中文翻译：
镉通过抑制十二指肠中的铁转运导致缺铁性贫血
镉 (Cd) 是一种环境污染物，会在肾脏、肝脏和肺等各种组织中引发毒性作用。镉还能引起铁代谢异常，导致贫血。铁稳态受肠道吸收调节。然而，Cd 是否影响铁吸收途径尚不清楚。我们旨在阐明肠道铁转运系统与 Cd 引起的缺铁性贫血之间的关系。C57BL/6 J 雌性和雄性小鼠、129/Sv 雌性小鼠和 DBA/2 雌性小鼠通过管饲法给予单次口服剂量的 CdCl2。3 或 24 小时后，Cd 降低血清铁浓度并抑制十二指肠中铁转运相关基因的表达。特别是，Cd 降低了十二指肠中二价金属转运蛋白 1 和铁转运蛋白 1 的水平。此外，人结肠癌 Caco-2 细胞用 CdCl2 处理。72 小时后，Cd 降低 Caco-2 细胞中铁转运相关因子的表达，其模式类似于在鼠十二指肠中看到的模式。这些发现表明，Cd 通过直接抑制十二指肠肠细胞中的铁转运来抑制铁的吸收，并导致铁代谢异常。
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