Pasteurella multocida possesses a viscous capsule polysaccharide on the cell surface, which is a critical structural component and virulence factor. Capsular polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immunological mechanism for bacterial molecular mimicry, resistance to phagocytosis, and immune evasion during the infection process. Based on the capsular antigen, P. multocida is divided into A, B, D, E, and F five serogroups. Previously, we systematically reported the biosynthesis and regulation mechanisms of the P. multocida capsule. In this paper, we take serogroup A capsular polysaccharide as the representative, systematically illuminating the P. multocida capsular virulence and epidemiology, molecular camouflage, adhesion and colonization, anti-phagocytosis, anti-complement system, cell invasion and signal transduction mechanism, to provide a theoretical basis for the research of molecular pathogenic mechanism of P. multocida capsule and the development of polysaccharides vaccine.

多杀巴斯德氏菌在细胞表面具有粘性胶囊多糖，这是关键的结构成分和毒力因子。荚膜多糖在结构上与脊椎动物的糖胺聚糖相似，在感染过程中为细菌分子模拟，抗吞噬作用和免疫逃避提供了免疫学机制。根据荚膜抗原，多杀性疟原虫分为A，B，D，E和F 5个血清群。以前，我们系统报道了P. multocida胶囊的生物合成和调控机制。本文以血清群A荚膜多糖为代表，系统地阐明了多杀疟原虫荚膜毒力和流行病学，分子伪装，粘附和定植，抗吞噬作用，抗补体系统，细胞侵袭和信号转导机制，为多杀青霉胶囊分子致病机理的研究和多糖的开发提供理论依据疫苗。