Cells are equipped with protein quality control pathways in order to maintain a healthy proteome; a process known as protein homeostasis. Dysfunction in protein homeostasis leads to the development of many diseases that are associated with proteinopathies. Recently, the rhomboid superfamily has attracted much attention concerning their involvement in protein homeostasis. While their functional role has become much clearer in the last few years, their systemic significance in mammals remains elusive. Here we delineate the current knowledge of rhomboids in protein quality control and how these functions are integrated at the organismal level.

中文翻译：

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菱形超家族成员在蛋白质稳态中的作用：机制洞察和生理意义。

细胞配备有蛋白质质量控​​制途径，以维持健康的蛋白质组；一个称为蛋白质稳态的过程。蛋白质稳态功能障碍会导致许多与蛋白质病相关的疾病的发生。最近，菱形超家族因其参与蛋白质稳态而备受关注。虽然它们的功能作用在过去几年中变得更加清晰，但它们在哺乳动物中的系统意义仍然难以捉摸。在这里，我们描述了菱形在蛋白质质量控​​制方面的最新知识，以及如何在有机体水平上整合这些功能。