Research on Chemical Intermediates ( IF 2.8 ) Pub Date : 2020-05-15 , DOI: 10.1007/s11164-020-04175-y Ammar Sheykhi-Estalkhjani , Nosrat O. Mahmoodi , Asieh Yahyazadeh , Meysam Pasandideh Nadamani
Some new DAMN-based Schiff base 6a–6g were synthesized via a condensation reaction of the corresponding azo dyes with 1-(2-amino-1,2-dicyanovinyl)-3-phenylurea. In continuation, facile synthesis of new 8,9-dihydro-7H-purine-6-carboxamide 7a–7g was reported via an efficient reaction of azo dyes and 1-(2-amino-1,2-dicyanovinyl)-3-phenylurea in the presence of triethylamine as catalyst. All the synthesized compounds were evaluated for their antibacterial activities against both Gram-positive (Micrococcus luteus and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria.
中文翻译:
二氨基马来腈基偶氮席夫碱和8,9-二氢-7 H-嘌呤-6-羧酰胺的合成及抗菌性能评价
通过相应的偶氮染料与1-(2-氨基-1,2-二氰基乙烯基)-3-苯基脲的缩合反应合成了一些基于DAMN的新Schiff碱6a – 6g。继续,通过偶氮染料和1-(2-氨基-1,2-二氰基ovyl)-3-的有效反应,据报道容易合成新的8,9-二氢-7 H-嘌呤-6-羧酰胺7a – 7g。苯脲在三乙胺的存在下作为催化剂。评价所有合成的化合物对革兰氏阳性(微球菌和金黄色葡萄球菌)和革兰氏阴性(铜绿假单胞菌和大肠杆菌)的抗菌活性。)细菌。