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Firmosides A and B: two new sucrose ferulates from the aerial parts of Silene firma and evaluation of radical scavenging activities.
Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2020-07-06 , DOI: 10.1007/s11418-020-01426-5
Nguyen Hoang Uyen 1 , Retno Widyowati 1, 2 , Melanny Ika Sulistyowaty 1, 3 , Sachiko Sugimoto 1 , Yoshi Yamano 1 , Susumu Kawakami 4 , Hideaki Otsuka 4 , Katsuyoshi Matsunami 1
Affiliation  

Abstract

Two new tri-ferulates of sucrose, firmosides A and B (1 and 2, respectively), together with 18 known compounds (320), were isolated from the aerial parts of Silene firma. The structures of the isolated compounds were elucidated by various spectroscopic methods, including 1D, 2D NMR, and high-resolution electro-spray ionization–mass spectrometry (HR-ESI–MS). All the isolated compounds were evaluated for their free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. As a result, two new compounds (1, 2) and 11 demonstrated significant radical scavenging activity, implying the usefulness as antioxidant agents.

Graphic Abstract



中文翻译:

Firmosides A和B:从Silene firma的空中部分提取的两个新蔗糖阿魏酸盐,并评估了其清除自由基的活性。

摘要

Silene firma的地上部分中分离出了两个新的蔗糖三阿魏酸,硬脂酸A和B(分别为12),以及18种已知化合物(320)。分离的化合物的结构通过各种光谱方法进行了阐明,包括1D,2D NMR和高分辨率电喷雾电离质谱(HR-ESI-MS)。使用1,1-二苯基-2-吡啶并肼基(DPPH)自由基评估所有分离的化合物的自由基清除活性。其结果是,两个新的化合物(12)和11 具有明显的自由基清除活性,这暗示了其作为抗氧化剂的有用性。

图形摘要

更新日期:2020-07-06
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