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The Structural-Functional Damage of Fibrinogen Oxidized by Hydrogen Peroxide.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-07-06 , DOI: 10.1134/s1607672920020167 L V Yurina 1, 2, 3, 4 , A D Vasilyeva 1 , V L Kononenko 1 , A E Bugrova 1 , M I Indeykina 1, 3 , A S Kononikhin 3 , E N Nikolaev 4 , M A Rosenfeld 1
中文翻译:
纤维蛋白原的结构功能损伤被过氧化氢氧化。
更新日期:2020-07-06
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-07-06 , DOI: 10.1134/s1607672920020167 L V Yurina 1, 2, 3, 4 , A D Vasilyeva 1 , V L Kononenko 1 , A E Bugrova 1 , M I Indeykina 1, 3 , A S Kononikhin 3 , E N Nikolaev 4 , M A Rosenfeld 1
Affiliation
Abstract
The effect of peroxide-induced oxidation of fibrinogen on modification of its primary structure and functional properties was investigated. The oxidation sites were shown to be Met, Trp, and His residues. Using the DLS method, it was found that the oxidative modification of fibrinogen results in the change of microrheological characteristics of fibrin network. The fibrinogen oxidation diminishes its tolerance to plasmin hydrolysis and deteriorates the factor XIIIa ability to stabilize the fibrin gel.中文翻译:
纤维蛋白原的结构功能损伤被过氧化氢氧化。