Abstract

The elaboration of modes for directed regulation of cell transition from the nonmotile fixed status to the motile state, and vice versa, is referred to the most important problems of practical medicine. Nowadays, the creation of biopreparations on the basis of naturally occurring compounds for the minimization or elimination of negative consequences at the cell malignization is an actual problem. The effect of synthetic peptide GERA (a fragment of antimicrobial polypeptides defensins) on the spreading and migration of embryonic fibroblasts was studied. The peptide was found to increase the number of spread cells in cell population compared to the control cells. In addition, the GERA peptide stimulates the directed migration of fibroblasts to wounded zone of cell monolayer (i.e., substrate areas free from cells). The most probable cell targets in spreading and migrating fibroblasts under peptide action are the structural and regulatory components of focal adhesions.

中文翻译：

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防御素寡肽片段控制成纤维细胞迁移和扩散的速率。

摘要

指导细胞从非活动性固定状态到活动性状态的转换的模式的详细阐述，反之亦然，是实践医学中最重要的问题。如今，基于自然存在的化合物产生生物制剂以最小化或消除细胞恶性反应的负面影响是一个实际问题。研究了合成肽GERA（抗微生物多肽防御素的片段）对胚胎成纤维细胞扩散和迁移的影响。与对照细胞相比，发现该肽增加了细胞群中扩散细胞的数量。另外，GERA肽刺激成纤维细胞定向迁移至细胞单层的受伤区域（即，没有细胞的底物区域）。