Abstract

A morphological and immunohistochemical study of periodontal tissues was performed in patients with chronic generalized periodontitis who underwent dental implantation. We studied 44 biopsy specimens from 21 patients (13 women and 8 men) aged 35–60 years with a diagnosis of periimplantation mucositis (7 patients), periimplantitis (8 patients), and severe chronic generalized periodontitis (6 patients). It was established that periimplantitis differs from periimplantation mucositis by a more pronounced inflammatory reaction with a clear predominance of plasma cells in the infiltrate, which captures the fibrous capsule around the implant, destroys it and further spreads to the bone tissue. Based on the immunohistochemical differences in SMA, VEGF, and Ki-67, it is concluded that periimplantation mucositis and periimplantitis are successive stages of progression of the same process. When comparing chronic generalized periodontitis and periimplantitis, the latter shows much more pronounced inflammatory and destructive processes in the area of the implant, due to the addition of immune inflammation, impaired regeneration processes, and destruction of bone tissue.

中文翻译：

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牙周炎和牙周炎的牙周组织炎症和再生过程的形态和分子生物学特征。

摘要

对接受牙种植的慢性全身性牙周炎患者的牙周组织进行了形态学和免疫组化研究。我们研究了年龄在35至60岁之间的21位患者（13位女性和8位男性）的44份活检标本，诊断为植入物周围粘膜炎（7例），植入物周围炎（8例）和严重的慢性全身性牙周炎（6例）。已经确定，植入物周围炎与植入物周围粘膜炎的区别在于，浸润物中浆细胞明显占优势，炎症反应更加明显，并捕获植入物周围的纤维囊，破坏其并进一步扩散至骨组织。根据SMA，VEGF和Ki-67的免疫组化差异，结论是，植入物周围粘膜炎和植入物周围炎是同一过程进展的连续阶段。当比较慢性全身性牙周炎和种植体周围炎时，由于增加了免疫炎症，受损的再生过程以及对骨组织的破坏，后者在植入物区域显示出更为明显的炎症和破坏性过程。