Background: Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favorable clinical outcome compared to other gliomas and a long-time survival that ranges between 10-20 years. However, during the course of the disease, multiple recurrences occur and the optimal treatment at each stage of the disease remains unclear. Here we report a retrospective longitudinal observation study of 836 MRI examinations in 44 ODG patients. Methods: We quantified the volume of T2-hyperintensity to compute growth behavior in dependence of different treatment modalities, using various computational models. Results: The identified growth pattern revealed dynamic changes, which were found to be patient-specific an did not correlate with clinical parameter or therapeutic interventions. Further, we showed that, surgical resection is beneficial for overall survival regardless the WHO grad or timepoint of surgery. To improve overall survival, an extent of resection above 50% is required. Multiple resections do not generally improve overall survival, except a greater extent of resection than in previous surgeries was achieved. Conclusions: Our data aids to improve the interpretation of MRI images in clinical practice.

中文翻译：

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少突胶质细胞瘤T2高强度的纵向转化特征

背景：少突胶质细胞瘤（ODG）是中枢神经系统耐药的肿瘤，其特征在于其独特的分子特征，即与IDH1 / 2突变同时缺失1p和19q。与其他神经胶质瘤相比，这些肿瘤的临床结局更佳，并且长期生存时间在10至20年之间。然而，在疾病过程中，会发生多次复发，并且在疾病的每个阶段的最佳治疗方案仍不清楚。在这里，我们报告了对44例ODG患者进行836例MRI检查的回顾性纵向观察研究。方法：我们使用各种计算模型量化了T2高强度的体积，以根据不同的治疗方式来计算生长行为。结果：确定的增长方式显示出动态变化，被发现是针对患者的，与临床参数或治疗干预措施无关。此外，我们表明，无论WHO等级或手术时间点如何，手术切除对整体生存都是有益的。为了提高总体生存率，要求切除率在50％以上。多次切除通常不能提高总体生存率，除非切除范围比以前的手术要大。结论：我们的数据有助于在临床实践中改善MRI图像的解释。多次切除通常不能提高总体生存率，除非切除范围比以前的手术要大。结论：我们的数据有助于在临床实践中改善MRI图像的解释。多次切除通常不能提高总体生存率，除非切除范围比以前的手术要大。结论：我们的数据有助于在临床实践中改善MRI图像的解释。