One third of people with epilepsy (PWE) continue to have seizures despite adequate antiepileptic drug treatment. This condition, known as drug-resistant epilepsy (DRE) significantly impairs their social, family and work environment. The aims of this study were to assess the quality of life (QoL) in PWE with DRE and to investigate which factors are associated with a better QoL. This was a cross-sectional observational study of 133 Latin American PWE. QoL was assessed with the Spanish version of the Quality of Life with Epilepsy questionnaire (QOLIE-10). Independent clinical variables were analyzed with non-parametric statistics and their association with QoL was investigated with multiple linear regression. Poor quality of life was found in 25.8% of PWE. A low number of antiepileptic drugs (AEDs) was the major factor associated with better quality of life, closely followed by seizure frequency. We conclude that careful selection of AED treatment may contribute to improving both seizure control and QoL.

中文翻译：

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拉丁美洲耐药性癫痫患者生活质量的决定因素：横断面相关研究

尽管进行了充分的抗癫痫药物治疗，仍有三分之一的癫痫病患者继续发作。这种情况被称为耐药性癫痫病（DRE），严重损害了他们的社交，家庭和工作环境。这项研究的目的是评估患有DRE的PWE患者的生活质量（QoL），并调查哪些因素与更好的QoL相关。这是对133个拉丁美洲PWE的横断面观察研究。使用西班牙语版的《癫痫患者生活质量调查表》（QOLIE-10）对生活质量进行了评估。使用非参数统计分析独立的临床变量，并使用多元线性回归研究它们与QoL的关联。25.8％的PWE发现生活质量差。少量的抗癫痫药是改善生活质量的主要因素，紧随其后的是癫痫发作频率。我们得出结论，仔细选择AED治疗可能有助于改善癫痫发作控制和QoL。