The two-component signalling systems PmrAB and PhoPQ of Salmonella have been extensively studied with regard to colistin resistance. We previously showed that overexpressed CpxR could significantly increase the colistin susceptibility (16-fold compared with the WT strain) of Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) through PmrAB and PhoPQ.

中文翻译：

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CpxR通过多目标机制调节鼠伤寒沙门氏菌的大肠菌素敏感性。

沙门氏菌的两组分信号系统PmrAB和PhoPQ已针对大肠菌素抗性进行了广泛研究。我们以前显示过表达的CpxR可以通过PmrAB和PhoPQ显着提高肠炎沙门氏菌血清鼠伤寒沙门氏菌（鼠伤寒沙门氏菌）的大肠菌素敏感性（与WT菌株相比，是16倍）。