RNA modifications are involved in various kinds of cellular biological processes. Accumulated evidences have demonstrated that the functions of RNA modifications are determined by the effectors that can catalyze, recognize and remove RNA modifications. They are called ‘writers’, ‘readers’ and ‘erasers’. The identification of RNA modification effectors will be helpful for understanding the regulatory mechanisms and biological functions of RNA modifications. In this work, we developed a database called RNAWRE that specially deposits RNA modification effectors. The current version of RNAWRE stored 2045 manually curated writers, readers and erasers for the six major kinds of RNA modifications, namely Cap, m¹A, m⁶A, m⁵C, ψ and Poly A. The main modules of RNAWRE not only allow browsing and downloading the RNA modification effectors but also support the BLAST search of the potential RNA modification effectors in other species. We hope that RNAWRE will be helpful for the researches on RNA modifications.

中文翻译：

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RNAWRE：RNA修饰的作者，读者和擦除者的资源。

RNA修饰涉及各种细胞生物学过程。积累的证据表明，RNA修饰的功能是由可以催化，识别和去除RNA修饰的效应子决定的。它们被称为“作家”，“读者”和“橡皮擦”。RNA修饰效应子的鉴定将有助于理解RNA修饰的调控机制和生物学功能。在这项工作中，我们开发了一个名为RNAWRE的数据库，该数据库专门存放RNA修饰效应子。当前版本的RNAWRE存储了2045个手动策划的写入器，读取器和擦除器，用于六种主要的RNA修改，即Cap，m ¹ A，m ⁶ A，m ⁵C，ψ和PolyA。RNAWRE的主要模块不仅允许浏览和下载RNA修饰效应子，还支持BLAST搜索其他物种中潜在的RNA修饰效应子。我们希望RNAWRE对RNA修饰的研究有所帮助。