Abstract

This review article highlights our efforts to decode the role of the nervous system in regulating intestinal lipid metabolism in Caenorhabditis elegans. Capitalizing on the prescient and pioneering work of Sydney Brenner and John Sulston in establishing C. elegans as an immensely valuable model system, we have uncovered critical roles for oxygen sensing, population density sensing and food sensing in orchestrating the balance between storing lipids and utilizing them for energy in the intestine, the major organ for lipid metabolism in this model system. Our long-term goal is to reveal the integrative mechanisms and regulatory logic that underlies the complex relationship between genes, environment and internal state in the regulation of energy and whole-body physiology.

摘要

这篇综述文章强调我们努力解读神经系统在秀丽隐杆线虫肠道脂质代谢调节中的作用。借助Sydney Brenner和John Sulston在建立线虫作为非常有价值的模型系统方面的先行先驱工作，我们发现了氧感测，人口密度感测和食物感测在协调存储和利用脂质之间的平衡方面的关键作用肠中的能量，是该模型系统中脂质代谢的主要器官。我们的长期目标是揭示在能量和全身生理调节中基因，环境和内部状态之间复杂关系基础的整合机制和调节逻辑。