Abstract

Context

Circulating uncarboxylated matrix Gla protein (ucMGP) is possibly related to coronary arterial calcification (CAC) in cardiovascular disease (CVD) patients.

Objective

We aimed to evaluate the relationships between circulating ucMGP, CVD pathology and CAC and its interplay with CVD risk factors.

Materials and methods

ucMGP was measured in 99 CVD-patients. CAC score was determined by multislice computed tomography. Circulating ucMGP, uncarboxylated (ucOC) and carboxylated osteocalcin (cOC) were assayed by ELISA kits. Vitamin-K status was evaluated by ucOC/cOC ratio.

Results

A tendency for decreased ucMGP was observed for CAC ≥ 100 AU vs. CAC = 1-99 AU after exclusion of the patients on vitamin K-antagonist anticoagulants. Significant inverse correlations between ucMGP and vitamin-K status were indicated for the entire cohort and according to CAC score. Significant associations were found between ucMGP and risk factors for CVD.

Conclusion

Circulating ucMGP may reflect certain stages of CVD and CAC. Future studies are needed to clarify its role as potential biomarker.

中文翻译：

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射血分数保留的心房颤动或心力衰竭患者的循环非羧化基质 Gla 蛋白

 抽象的

 语境

循环非羧化基质 Gla 蛋白 (ucMGP) 可能与心血管疾病 (CVD) 患者的冠状动脉钙化 (CAC) 有关。

 客观的

我们的目的是评估循环 ucMGP、CVD 病理学和 CAC 之间的关系及其与 CVD 危险因素的相互作用。

 材料和方法

对 99 名 CVD 患者进行了 ucMGP 测量。 CAC 评分通过多层计算机断层扫描确定。通过 ELISA 试剂盒测定循环 ucMGP、未羧化骨钙素 (ucOC) 和羧化骨钙素 (cOC)。维生素 K 状态通过 ucOC/cOC 比率进行评估。

 结果

观察到 CAC 的 ucMGP 呈下降趋势 ≥ 100 AU 与 CAC = 1-99 排除使用维生素 K 拮抗剂抗凝剂的患者后的 AU。根据 CAC 评分，整个队列的 ucMGP 和维生素 K 状态之间存在显着负相关。研究发现 ucMGP 与 CVD 危险因素之间存在显着相关性。

 结论

循环的 ucMGP 可能反映 CVD 和 CAC 的某些阶段。未来的研究需要阐明其作为潜在生物标志物的作用。