Background

Many studies support the hypothesis that brain glucose dysregulation contributes to neurodegeneration and disease progression. The SLC2A3 gene encodes the Neuronal Glucose Transporter 3 (GLUT3), a critical molecule for glucose transport into the neuron. The GLUT3 rs12842 polymorphism has been associated with an increased risk for attention-deficit/hyperactivity disorder (ADHD). Epidemiological and genetic studies have reported a link between antecedent ADHD and Alzheimer’s disease (AD), as both share a dysregulation of brain glucose.

Aim

This study aimed to explore the possible correlation of the SLC2A3 rs12842 polymorphism with susceptibility towards AD.

Methods

We genotyped 327 patients with AD and 327 controls for the GLUT3 rs12842. Results: Rs12842 was associated with a decreased risk of developing AD in the co-dominant [Odds Ratio (OR) (95% confidence interval (CI) = 0.67 (0.45–0.99)), p = 0.039], dominant [OR (95% CI) = 0.64 (0.44–0.93), p = 0.019] and log-additive modes [OR (95% CI) = 0.65 (0.46–0.91), p = 0.012].

Conclusions

Our results suggest a significant, inverse association between SLC2A3 rs12842 and the risk of AD.

中文翻译：

---

SLC2A3 rs12842多态性和阿尔茨海默氏病风险。

背景

许多研究支持以下假设：大脑葡萄糖失调会导致神经退行性病变和疾病进展。SLC2A3基因编码神经元葡萄糖转运蛋白3（GLUT3），这是葡萄糖向神经元转运的关键分子。GLUT3 rs12842多态性与注意力不足/多动症（ADHD）的风险增加有关。流行病学和遗传学研究已经报道了先天性多动症与阿尔茨海默氏病（AD）之间存在联系，因为两者均患有脑葡萄糖调节异常。

目标

这项研究旨在探讨SLC2A3 rs12842多态性与对AD的敏感性之间的可能关系。

方法

我们对327例AD患者和327例GLUT3 rs12842对照进行了基因分型。结果：Rs12842与共同优势[AD的赔率（OR）（95％置信区间（CI）= 0.67（0.45–0.99）），p = 0.039]，优势[OR（95） ％CI）= 0.64（0.44-0.93），p = 0.019]和对数加性模式[OR（95％CI）= 0.65（0.46-0.91），p = 0.012]。

结论

我们的结果表明SLC2A3 rs12842与AD风险之间存在显着的负相关关系。