Introduction

Drug delivery systems with extended-release profiles are ideal in improving patient compliance with enhanced efficacy. To develop devices capable of a prolonged delivery kinetics, it is crucial to understand the various underlying mechanisms contributing to extended drug release and the impact thereof on modulating the long-term performance of such systems in a practical application environment.

Areas covered

This review article intends to provide a comprehensive summary of release mechanisms in extended-release drug delivery systems, particularly polymer-based systems; however, other material types will also be mentioned. Selected current research in the delivery of small molecule drugs and macromolecules is highlighted. Emphasis is placed on the combined impact of different release mechanisms and drug properties on the long-term release kinetics in vitro and in vivo.

Expert opinion

The development of drug delivery systems over an extended duration is promising but also challenging when considering the numerous interrelated delivery-related parameters. Achieving a well-controlled extended drug release requires advanced techniques to minimize burst release and lag phase, a better understanding of the dynamic interrelationship between drug properties and release profiles over time, and a thorough elucidation of the impact of multiple in vivo conditions to methodically evaluate the eventual clinical efficacy.

中文翻译：

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缓释药物递送系统的释放机制和应用。

介绍

具有延长释放曲线的药物输送系统是提高患者依从性和增强功效的理想之选。为了开发能够延长递送动力学的装置，至关重要的是要了解导致药物释放延长的各种潜在机制及其在实际应用环境中对调节此类系统的长期性能的影响。

覆盖区域

本文旨在提供缓释药物递送系统（尤其是基于聚合物的系统）中释放机制的全面摘要；然而，还将提及其他材料类型。重点介绍了在小分子药物和大分子输送方面的最新研究成果。重点放在体外和体内不同释放机制和药物特性对长期释放动力学的综合影响上。

专家意见

在考虑众多相互关联的与传递相关的参数时，药物传递系统在较长时间内的发展是有希望的，但同时也具有挑战性。要实现良好控制的延长药物释放，需要先进的技术来最大程度地减少突发释放和滞后阶段，更好地了解随着时间的推移药物特性和释放曲线之间的动态相互关系，并彻底阐明多种体内条件的影响以系统地评估最终的临床疗效。