The colorful versatility of adipocytes: white-to-brown transdifferentiation and its therapeutic potential in humans,The FEBS Journal

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The colorful versatility of adipocytes: white-to-brown transdifferentiation and its therapeutic potential in humans
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-07-03 , DOI: 10.1111/febs.15470
Stefanie Maurer ₁ , Matthew Harms ₁ , Jeremie Boucher _{1,

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Affiliation

Brown and brite adipocytes contribute to energy expenditure through nonshivering thermogenesis. Though these cell types are thought to arise primarily from the de novo differentiation of precursor cells, their abundance is also controlled through the transdifferentiation of mature white adipocytes. Here, we review recent advances in our understanding of the regulation of white-to-brown transdifferentiation, as well as the conversion of brown and brite adipocytes to dormant, white-like fat cells. Converting mature white adipocytes into brite cells or reactivating dormant brown and brite adipocytes has emerged as a strategy to ameliorate human metabolic disorders. We analyze the evidence of learning from mice and how they translate to humans to ultimately scrutinize the relevance of this concept. Moreover, we estimate that converting a small percentage of existing white fat mass in obese subjects into active brite adipocytes could be sufficient to achieve meaningful benefits in metabolism. In conclusion, novel browning agents have to be identified before adipocyte transdifferentiation can be realized as a safe and efficacious therapy.

中文翻译：

脂肪细胞的多彩多功能性：白到棕色的转分化及其在人类中的治疗潜力

Brown 和 brite 脂肪细胞通过非颤抖的产热作用促进能量消耗。虽然这些细胞类型被认为主要来自于新生前体细胞的分化，它们的丰度也通过成熟的白色脂肪细胞的转分化来控制。在这里，我们回顾了我们对白到棕色转分化调控以及棕色和黑色脂肪细胞转化为休眠的白色样脂肪细胞的理解的最新进展。将成熟的白色脂肪细胞转化为 Brite 细胞或重新激活休眠的棕色和 Brite 脂肪细胞已成为改善人类代谢紊乱的一种策略。我们分析了从老鼠身上学习的证据以及它们如何转化为人类，以最终审查这一概念的相关性。此外，我们估计将肥胖受试者中一小部分现有的白色脂肪转化为活跃的脂肪细胞可能足以在新陈代谢中获得有意义的益处。综上所述，

更新日期：2020-07-03

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